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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK3
All Species:
41.21
Human Site:
Y451
Identified Species:
64.76
UniProt:
O43781
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43781
NP_001004023.1
588
65714
Y451
N
S
K
G
I
P
R
Y
C
S
V
T
T
Q
A
Chimpanzee
Pan troglodytes
XP_524527
588
65774
Y451
N
S
K
G
I
P
R
Y
C
S
V
T
T
Q
A
Rhesus Macaque
Macaca mulatta
XP_001086117
588
65769
Y451
N
S
K
G
I
P
R
Y
C
S
V
T
T
Q
A
Dog
Lupus familis
XP_537131
637
71340
Y501
N
S
K
G
L
P
R
Y
C
S
V
T
T
Q
A
Cat
Felis silvestris
Mouse
Mus musculus
Q922Y0
586
65553
Y450
N
S
K
G
L
P
R
Y
C
S
V
S
T
Q
T
Rat
Rattus norvegicus
Q4V8A3
586
65492
Y450
N
S
K
G
L
P
R
Y
C
S
V
T
T
Q
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511087
546
60615
Y410
S
S
K
G
Y
P
R
Y
C
A
V
T
T
L
S
Chicken
Gallus gallus
Q5ZIU3
526
59419
Y389
S
S
K
G
Y
P
R
Y
C
T
I
T
T
L
S
Frog
Xenopus laevis
NP_001088793
567
63329
Y431
N
S
K
G
Y
P
R
Y
C
T
V
T
T
L
P
Zebra Danio
Brachydanio rerio
NP_001108400
581
65351
Y442
S
S
K
G
H
P
R
Y
C
T
V
S
T
L
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P83102
828
92722
Y518
S
P
K
G
Y
P
R
Y
C
T
V
R
T
M
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_001023207
817
89866
P680
I
I
E
L
L
G
M
P
P
P
K
S
L
E
T
Sea Urchin
Strong. purpuratus
XP_799140
561
63192
K424
I
D
T
S
K
R
S
K
N
F
I
N
S
K
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51566
467
54180
S334
C
I
L
V
E
L
C
S
G
E
A
L
F
Q
T
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
I633
E
F
C
R
E
Y
N
I
V
E
K
P
S
K
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.8
85.7
N.A.
89.6
90.8
N.A.
57.9
59
65.3
63.4
N.A.
39
N.A.
40.5
54.7
Protein Similarity:
100
99.4
99.4
88.8
N.A.
93.5
94.2
N.A.
70.7
71.9
77.8
76.6
N.A.
50.9
N.A.
52.5
68.3
P-Site Identity:
100
100
100
93.3
N.A.
80
86.6
N.A.
66.6
60
73.3
60
N.A.
53.3
N.A.
0
0
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
86.6
86.6
80
86.6
N.A.
73.3
N.A.
26.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.2
26.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.7
41
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
7
7
0
0
0
27
% A
% Cys:
7
0
7
0
0
0
7
0
74
0
0
0
0
0
0
% C
% Asp:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
7
0
7
0
14
0
0
0
0
14
0
0
0
7
0
% E
% Phe:
0
7
0
0
0
0
0
0
0
7
0
0
7
0
0
% F
% Gly:
0
0
0
74
0
7
0
0
7
0
0
0
0
0
7
% G
% His:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
14
14
0
0
20
0
0
7
0
0
14
0
0
0
0
% I
% Lys:
0
0
74
0
7
0
0
7
0
0
14
0
0
14
0
% K
% Leu:
0
0
7
7
27
7
0
0
0
0
0
7
7
27
0
% L
% Met:
0
0
0
0
0
0
7
0
0
0
0
0
0
7
0
% M
% Asn:
47
0
0
0
0
0
7
0
7
0
0
7
0
0
0
% N
% Pro:
0
7
0
0
0
74
0
7
7
7
0
7
0
0
7
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
47
7
% Q
% Arg:
0
0
0
7
0
7
74
0
0
0
0
7
0
0
0
% R
% Ser:
27
67
0
7
0
0
7
7
0
40
0
20
14
0
27
% S
% Thr:
0
0
7
0
0
0
0
0
0
27
0
54
74
0
27
% T
% Val:
0
0
0
7
0
0
0
0
7
0
67
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
27
7
0
74
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _